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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Nolan Ryan* | 5714 | 1966-1993 | |
| 2 | Matt Gilman* | 5306 | 2051-2071 | |
| 3 | Mario Segura* | 5139 | 2060-2080 | |
| 4 | Randy Johnson* | 4875 | 1988-2009 | |
| 5 | Javier Covarrubias* | 4690 | 2061-2077 | |
| 6 | Roger Clemens | 4672 | 1984-2007 | |
| 7 | Pat Ogden* | 4476 | 2040-2061 | |
| 8 | Jaylen Watts* | 4278 | 2067-2086 | |
| 9 | Juan Fernandez* | 4154 | 2053-2066 | |
| 10 | Steve Carlton* | 4136 | 1965-1988 | |
| 11 | Jose Rubio* | 3991 | 2060-2079 | |
| 12 | Asher Robert* | 3990 | 2057-2072 | |
| 13 | Clayton Kershaw* | 3885 | 2008-2029 | |
| 14 | Evan Parker* | 3759 | 2070-2086 | |
| 15 | Alex Batista* | 3746 | 2058-2073 | |
| 16 | Bert Blyleven* | 3701 | 1970-1992 | |
| 17 | Steve Chase | 3693 | 2078-2093 | |
| 18 | Devin Carl* | 3645 | 2026-2043 | |
| 19 | Tom Seaver* | 3640 | 1967-1986 | |
| 20 | Don Sutton* | 3574 | 1966-1988 | |
| 21 | Danny Simas | 3571 | 2078-2095 | |
| 22 | Graham Trace | 3541 | 2078-2097 | |
| 23 | Gabe Fay* | 3534 | 2069-2089 | |
| 23 | Gaylord Perry* | 3534 | 1962-1983 | |
| 25 | Walter Johnson* | 3509 | 1907-1927 | |
| 26 | David DePriest* | 3485 | 2051-2064 | |
| 27 | Phil Harfst* | 3466 | 2050-2067 | |
| 28 | Josh Lowe | 3460 | 2033-2047 | |
| 29 | Joe Phillips | 3452 | 2028-2043 | |
| 30 | Pat Champlin | 3405 | 2079-2095 | |
| 31 | Claudio Scotti* | 3372 | 2018-2035 | |
| 32 | Greg Maddux* | 3371 | 1986-2008 | |
| 33 | Javier Venzor* | 3356 | 2022-2041 | |
| 34 | Phil Niekro* | 3342 | 1964-1987 | |
| 35 | Steve Ewins | 3327 | 2028-2043 | |
| 36 | Ken Steinberg | 3317 | 2053-2070 | |
| 37 | Manny Cruz* | 3311 | 2027-2043 | |
| 38 | Roberto Vidana | 3273 | 2024-2037 | |
| 39 | Luis Garcia | 3231 | 2057-2073 | |
| 40 | Justin Block | 3222 | 2041-2058 | |
| 41 | Fergie Jenkins* | 3192 | 1965-1983 | |
| 42 | J.B. Bukauskas* | 3180 | 2019-2036 | |
| 43 | Steve Hoskins | 3174 | 2055-2073 | |
| 44 | Pedro Martinez* | 3154 | 1992-2009 | |
| 45 | David Amaya | 3141 | 2055-2073 | |
| 46 | Felix Hernandez* | 3126 | 2005-2022 | |
| 47 | Bob Gibson* | 3117 | 1959-1975 | |
| 48 | Curt Schilling | 3116 | 1988-2007 | |
| 49 | Jose Cruz# | 3106 | 2085-2097 | |
| 50 | Steve Coutts | 3095 | 2077-2094 | |
| 51 | Brian Anderson | 3090 | 2052-2066 | |
| 52 | John Smoltz* | 3084 | 1988-2009 | |
| 53 | Javier Huerta | 3046 | 2055-2069 | |
| 54 | Max Reyes* | 3045 | 2031-2046 | |
| 55 | Max Scherzer* | 3025 | 2008-2024 | |
| 56 | John Barcalow | 3021 | 2076-2089 | |
| 57 | Stephen Strasburg | 2975 | 2010-2030 | |
| 58 | Manny Baez | 2971 | 2069-2083 | |
| 59 | Jordan Pardo Jr. | 2967 | 2080-2095 | |
| 60 | Danny Gil | 2955 | 2073-2087 | |
| 61 | Andy Mediate | 2927 | 2070-2088 | |
| 62 | Josh Jackson | 2925 | 2061-2074 | |
| 63 | Matt Whisler* | 2881 | 2042-2056 | |
| 64 | Jorge Mariscal | 2874 | 2060-2076 | |
| 65 | Adonis Medina | 2872 | 2019-2035 | |
| 66 | Jim Bunning* | 2855 | 1955-1971 | |
| 67 | Roberto Arceo* | 2853 | 2033-2049 | |
| 68 | Antonio Pagan | 2845 | 2047-2059 | |
| 69 | Chris Sale* | 2839 | 2010-2025 | |
| 70 | Cole Hamels | 2837 | 2006-2022 | |
| 71 | Mickey Lolich | 2832 | 1963-1979 | |
| 72 | Logan Lowe* | 2829 | 2062-2079 | |
| 73 | Mike Mussina | 2813 | 1991-2008 | |
| 74 | Jeremy Fields | 2805 | 2052-2070 | |
| 75 | Cy Young* | 2803 | 1890-1911 | |
| 76 | Jon Meger# | 2795 | 2082-2097 | |
| 77 | Fred Cloninger* | 2792 | 2033-2044 | |
| 77 | Tony Juarez | 2792 | 2051-2064 | |
| 79 | Leo Monrreal* | 2791 | 2031-2044 | |
| 80 | Joe McCumbee | 2789 | 2063-2079 | |
| 81 | Colby Brown | 2775 | 2057-2068 | |
| 82 | Adam Herbert | 2773 | 2077-2090 | |
| 82 | Frank Tanana | 2773 | 1973-1993 | |
| 82 | Landon Welday | 2773 | 2052-2071 | |
| 85 | Andy Pfrommer | 2763 | 2020-2041 | |
| 86 | Nick Farrier# | 2748 | 2084-2097 | |
| 87 | Rafael Pulido | 2740 | 2057-2074 | |
| 88 | Rodrigo Santana# | 2736 | 2083-2097 | |
| 89 | Carlos Rodon | 2734 | 2015-2031 | |
| 90 | Dave Upton | 2724 | 2062-2075 | |
| 91 | Gus Mejia | 2720 | 2036-2050 | |
| 92 | Edwin Morel | 2719 | 2065-2081 | |
| 93 | Curt Moffatt | 2715 | 2025-2042 | |
| 94 | Armando Almodovar* | 2709 | 2020-2035 | |
| 95 | Zack Greinke* | 2702 | 2004-2022 | |
| 96 | Bobby Peron | 2701 | 2028-2044 | |
| 97 | Hugo Vega | 2699 | 2072-2088 | |
| 98 | Justin Cresswell | 2697 | 2024-2036 | |
| 99 | Hagen Danner | 2693 | 2020-2035 | |
| 100 | Brian Clouse | 2689 | 2047-2060 |
