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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | SV | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Liu-chun Cui* | 33 | 2038-2053 | |
| 2 | Braxton Janke | 26 | 2046-2060 | |
| 3 | Doug Hodges | 22 | 2078-2093 | |
| 4 | Bobby Fenelon | 17 | 2085-2097 | |
| 5 | Jeurys Familia | 16 | 2012-2032 | |
| 6 | Jacob Lindgren | 15 | 2015-2031 | |
| 6 | Julio Montano | 15 | 2056-2068 | |
| 6 | Jim Stephens | 15 | 2068-2078 | |
| 9 | Ben Bradford | 14 | 2081-2093 | |
| 9 | Bob Decoste | 14 | 2025-2038 | |
| 9 | Sandy Ortega | 14 | 2075-2089 | |
| 12 | Neil Abrams | 13 | 2032-2044 | |
| 12 | Yunior Perez* | 13 | 2021-2037 | |
| 12 | Paul Welt | 13 | 2060-2072 | |
| 15 | Roberto Villarreal | 12 | 2062-2074 | |
| 16 | Matthew Dress | 11 | 2052-2069 | |
| 16 | Izzy Gonzalez | 11 | 2026-2040 | |
| 18 | Brandon Alexander | 10 | 2085-2098 | |
| 18 | Tyler Gorman | 10 | 2080-2096 | |
| 18 | Phil Graham | 10 | 2067-2077 | |
| 18 | Rich Robichaud | 10 | 2031-2046 | |
| 18 | Chris Saunders | 10 | 2042-2051 | |
| 23 | Dellin Betances | 9 | 2011-2029 | |
| 23 | Alberto Casanas | 9 | 2019-2031 | |
| 23 | Alfredo Ceja | 9 | 2040-2055 | |
| 23 | Chris Clark | 9 | 2072-2086 | |
| 23 | Jimmy Crowden | 9 | 2024-2033 | |
| 23 | Josh Farley | 9 | 2079-2096 | |
| 23 | Josh Potter | 9 | 2056-2069 | |
| 23 | Nick Ray | 9 | 2083-2096 | |
| 23 | Mauricio Soto | 9 | 2080-2094 | |
| 23 | Justin Trimble | 9 | 2027-2037 | |
| 23 | Dan White | 9 | 2077-2091 | |
| 34 | Jose Amaro# | 8 | 2085-2098 | |
| 34 | Bernie Escalante | 8 | 2029-2041 | |
| 34 | Jason Garcia | 8 | 2015-2026 | |
| 34 | Ken Giles | 8 | 2014-2030 | |
| 34 | Eric Klunder | 8 | 2071-2081 | |
| 34 | Jay Malvitz | 8 | 2044-2055 | |
| 34 | Fernando Roman | 8 | 2057-2070 | |
| 34 | Kyle Serrano | 8 | 2020-2032 | |
| 42 | Val Alvarez | 7 | 2016-2035 | |
| 42 | Nate Boyd | 7 | 2055-2063 | |
| 42 | Juan Castorena | 7 | 2053-2070 | |
| 42 | Alastair Colson | 7 | 2074-2091 | |
| 42 | Aaron Fields# | 7 | 2086-2098 | |
| 42 | Drew Goodwin# | 7 | 2095-2098 | |
| 42 | Mike Kelley | 7 | 2022-2035 | |
| 42 | Carlos Montanez | 7 | 2042-2055 | |
| 42 | Guy Oatis | 7 | 2040-2052 | |
| 42 | Trevor Rosenthal | 7 | 2012-2027 | |
| 42 | Edwin Salcedo | 7 | 2029-2036 | |
| 42 | Bobby Tapia | 7 | 2082-2097 | |
| 42 | Logan Webb | 7 | 2021-2028 | |
| 42 | George Zimmerman | 7 | 2052-2065 | |
| 56 | Danny Aristondo | 6 | 2026-2038 | |
| 56 | Ryan Bakken | 6 | 2047-2057 | |
| 56 | Carter Capps | 6 | 2012-2025 | |
| 56 | Trevor Dillon | 6 | 2036-2055 | |
| 56 | Rico Flores | 6 | 2075-2088 | |
| 56 | Robby Gallegos | 6 | 2024-2040 | |
| 56 | Mike Hartnagel# | 6 | 2084-2098 | |
| 56 | J.R. Henley | 6 | 2044-2058 | |
| 56 | Jon Hoch | 6 | 2076-2091 | |
| 56 | Kenley Jansen | 6 | 2010-2026 | |
| 56 | Gustavo Jimenez | 6 | 2058-2070 | |
| 56 | Matt Jordan | 6 | 2058-2072 | |
| 56 | Corey Knebel | 6 | 2014-2025 | |
| 56 | Greg Lantz | 6 | 2030-2044 | |
| 56 | Keith Lau | 6 | 2035-2051 | |
| 56 | Jeremy LeVan | 6 | 2053-2064 | |
| 56 | Jorge Mariscal | 6 | 2060-2076 | |
| 56 | Corey Negron | 6 | 2022-2037 | |
| 56 | Justin Parchman | 6 | 2070-2080 | |
| 56 | Jonathan Pitrone | 6 | 2026-2036 | |
| 56 | Joe Riedel | 6 | 2046-2060 | |
| 56 | Jared Rzepka | 6 | 2042-2051 | |
| 56 | Alex Soto* | 6 | 2068-2087 | |
| 56 | Jeremy Stroud | 6 | 2070-2084 | |
| 56 | Art Tesar# | 6 | 2086-2098 | |
| 81 | Danny Avery | 5 | 2054-2069 | |
| 81 | Alex Batista* | 5 | 2058-2073 | |
| 81 | George Bramwell* | 5 | 2023-2044 | |
| 81 | Brady Brownfield | 5 | 2025-2041 | |
| 81 | Josh Burkhart | 5 | 2060-2071 | |
| 81 | Harry DeBiase | 5 | 2055-2071 | |
| 81 | Nick Doyle | 5 | 2053-2061 | |
| 81 | B.J. Edwards# | 5 | 2093-2098 | |
| 81 | Joe Fitch | 5 | 2031-2042 | |
| 81 | Pat Fitzgerald* | 5 | 2045-2061 | |
| 81 | Shawn Kelley | 5 | 2009-2020 | |
| 81 | Jose Madrigal | 5 | 2057-2071 | |
| 81 | Corey Meyer | 5 | 2025-2035 | |
| 81 | Tadatoki Nakayama | 5 | 2039-2044 | |
| 81 | Jonathan Papelbon | 5 | 2005-2022 | |
| 81 | Sean Pester | 5 | 2042-2052 | |
| 81 | Jason Ralph | 5 | 2055-2072 | |
| 81 | Irvin Rife | 5 | 2080-2093 | |
| 81 | Jose Rubio* | 5 | 2060-2079 | |
| 81 | Vince Williams | 5 | 2029-2039 |
