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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | RBI | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Eduardo Lopez# | 164 | 2097 | |
| 2 | Alex Rodriguez* | 156 | 2007 | |
| 3 | John Esposto* | 150 | 2074 | |
| 4 | Jonathan Setzler# | 148 | 2089 | |
| 5 | Al Rosen | 145 | 1953 | |
| 5 | Joey Gallo | 145 | 2017 | |
| 7 | Vinny Castilla | 144 | 1998 | |
| 8 | Matt Williams | 142 | 1999 | |
| 9 | Mike Woodard# | 141 | 2098 | |
| 9 | Joe Fowler# | 141 | 2093 | |
| 11 | Harmon Killebrew* | 140 | 1969 | |
| 11 | Phil Ruffner | 140 | 2037 | |
| 13 | Mike Woodard# | 139 | 2092 | |
| 13 | Miguel Cabrera* | 139 | 2012 | |
| 15 | Russ Conrad | 138 | 2086 | |
| 15 | John Esposto* | 138 | 2076 | |
| 17 | Jacob Walker | 137 | 2040 | |
| 17 | Miguel Cabrera* | 137 | 2013 | |
| 17 | Joe Torre* | 137 | 1971 | |
| 17 | Chris Alderman* | 137 | 2040 | |
| 17 | Lee Tasso | 137 | 2073 | |
| 22 | Jake Ammons | 136 | 2051 | |
| 23 | Eddie Mathews* | 135 | 1953 | |
| 23 | Danny Gamez | 135 | 2073 | |
| 25 | Blake Loomis* | 134 | 2078 | |
| 25 | Russ Conrad | 134 | 2087 | |
| 27 | John Esposto* | 133 | 2078 | |
| 28 | Jimmy Collins* | 132 | 1897 | |
| 29 | Josh Turner | 131 | 2044 | |
| 29 | Vinny Castilla | 131 | 2004 | |
| 31 | Deron Johnson | 130 | 1965 | |
| 31 | Nolan Arenado | 130 | 2015 | |
| 31 | Ken Caminiti | 130 | 1996 | |
| 31 | Frank Baker* | 130 | 1912 | |
| 31 | Albert Pujols* | 130 | 2001 | |
| 31 | Mike Woodard# | 130 | 2091 | |
| 31 | Ryan Levine | 130 | 2061 | |
| 31 | Alex Rodriguez* | 130 | 2005 | |
| 31 | Ryan Levine | 130 | 2060 | |
| 40 | Chris Alderman* | 129 | 2043 | |
| 40 | Chris Meredith | 129 | 2049 | |
| 40 | Mike Woodard# | 129 | 2096 | |
| 40 | Tony Perez* | 129 | 1970 | |
| 44 | Antonio de Oleo | 128 | 2085 | |
| 45 | Blake Sucic | 127 | 2058 | |
| 45 | Lee Tasso | 127 | 2075 | |
| 45 | Paul DeJong | 127 | 2020 | |
| 45 | Antonio Borunda | 127 | 2056 | |
| 45 | Jonathan Setzler# | 127 | 2090 | |
| 50 | Phil Nevin | 126 | 2001 | |
| 50 | Mike Woodard# | 126 | 2093 | |
| 52 | Alex Rodriguez* | 125 | 2010 | |
| 52 | Zackary Reeder | 125 | 2030 | |
| 52 | Nate Parker | 125 | 2030 | |
| 52 | Phil Ruffner | 125 | 2040 | |
| 52 | Lave Cross | 125 | 1894 | |
| 57 | Ryan McMahon* | 124 | 2021 | |
| 57 | Gerolamo Taschini | 124 | 2065 | |
| 57 | Scott Rolen | 124 | 2004 | |
| 57 | Eddie Mathews* | 124 | 1960 | |
| 57 | David Wright | 124 | 2008 | |
| 57 | Pie Traynor* | 124 | 1928 | |
| 57 | Nolan Arenado | 124 | 2019 | |
| 57 | Pinky Whitney | 124 | 1932 | |
| 65 | Ron Santo* | 123 | 1969 | |
| 65 | John Esposto* | 123 | 2077 | |
| 65 | Vince Angeloff | 123 | 2046 | |
| 65 | Melvin Cruz | 123 | 2033 | |
| 65 | Mike Woodard# | 123 | 2095 | |
| 65 | Billy Nash | 123 | 1893 | |
| 65 | Phil Ruffner | 123 | 2035 | |
| 65 | Jason Richford | 123 | 2084 | |
| 65 | Josh Donaldson | 123 | 2015 | |
| 65 | Tim Wallach | 123 | 1987 | |
| 75 | Chris Alderman* | 122 | 2041 | |
| 75 | Joey Gallo | 122 | 2019 | |
| 75 | Mike Woodard# | 122 | 2097 | |
| 75 | Marty Cruz | 122 | 2077 | |
| 75 | Tony Perez* | 122 | 1969 | |
| 75 | Melvin Cruz | 122 | 2040 | |
| 75 | Matt Williams | 122 | 1990 | |
| 75 | Joe Andrews | 122 | 2076 | |
| 83 | Antonio Borunda | 121 | 2059 | |
| 83 | Alex Perez# | 121 | 2094 | |
| 83 | Adrian Beltre* | 121 | 2004 | |
| 83 | Chris Meredith | 121 | 2051 | |
| 83 | Alex Rodriguez* | 121 | 2006 | |
| 83 | Wil Alvarez | 121 | 2063 | |
| 83 | Mike Schmidt* | 121 | 1980 | |
| 90 | Robin Ventura | 120 | 1999 | |
| 90 | Hank Majeski | 120 | 1948 | |
| 90 | Frank Goerig | 120 | 2068 | |
| 90 | John Esposto* | 120 | 2079 | |
| 90 | Garrett Atkins | 120 | 2006 | |
| 90 | Larry Gardner | 120 | 1921 | |
| 90 | Bobby Avalos | 120 | 2063 | |
| 90 | Mike Lowell | 120 | 2007 | |
| 98 | Aramis Ramirez | 119 | 2006 | |
| 98 | Mike Schmidt* | 119 | 1986 | |
| 98 | Pie Traynor* | 119 | 1930 |
