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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Cy Young* | 511 | 1890-1911 | |
| 2 | Walter Johnson* | 417 | 1907-1927 | |
| 3 | Pete Alexander* | 373 | 1911-1930 | |
| 3 | Christy Mathewson* | 373 | 1900-1916 | |
| 5 | Warren Spahn* | 363 | 1942-1965 | |
| 6 | Pud Galvin* | 361 | 1875-1892 | |
| 6 | Kid Nichols* | 361 | 1890-1906 | |
| 8 | Greg Maddux* | 355 | 1986-2008 | |
| 9 | Roger Clemens | 354 | 1984-2007 | |
| 10 | Matt Gilman* | 351 | 2051-2071 | |
| 11 | Tim Keefe* | 342 | 1880-1893 | |
| 12 | Steve Carlton* | 329 | 1965-1988 | |
| 13 | John Clarkson* | 328 | 1882-1894 | |
| 14 | Nolan Ryan* | 324 | 1966-1993 | |
| 14 | Don Sutton* | 324 | 1966-1988 | |
| 16 | Phil Niekro* | 318 | 1964-1987 | |
| 17 | Gaylord Perry* | 314 | 1962-1983 | |
| 18 | Tom Seaver* | 311 | 1967-1986 | |
| 19 | Mickey Welch* | 307 | 1880-1892 | |
| 20 | Tom Glavine* | 305 | 1987-2008 | |
| 20 | Eddie Plank* | 305 | 1901-1917 | |
| 22 | Randy Johnson* | 303 | 1988-2009 | |
| 23 | Gabe Fay* | 301 | 2069-2089 | |
| 24 | Lefty Grove* | 300 | 1925-1941 | |
| 24 | Early Wynn* | 300 | 1939-1963 | |
| 26 | Tommy John | 288 | 1963-1989 | |
| 27 | Bert Blyleven* | 287 | 1970-1992 | |
| 28 | Robin Roberts* | 286 | 1948-1966 | |
| 28 | Jaylen Watts* | 286 | 2067-2086 | |
| 30 | Fergie Jenkins* | 284 | 1965-1983 | |
| 31 | Jim Kaat | 283 | 1959-1983 | |
| 32 | Charley Radbourn* | 282 | 1881-1891 | |
| 33 | Red Ruffing* | 273 | 1924-1947 | |
| 34 | Burleigh Grimes* | 270 | 1916-1934 | |
| 34 | Mike Mussina | 270 | 1991-2008 | |
| 36 | Jamie Moyer | 269 | 1986-2012 | |
| 37 | Jim Palmer* | 268 | 1965-1984 | |
| 38 | Bob Feller* | 266 | 1936-1956 | |
| 38 | Eppa Rixey* | 266 | 1912-1933 | |
| 40 | Mario Segura* | 265 | 2060-2080 | |
| 41 | Pat Ogden* | 262 | 2040-2061 | |
| 42 | Ted Lyons* | 260 | 1923-1946 | |
| 43 | Clayton Kershaw* | 259 | 2008-2029 | |
| 44 | Andy Pettitte | 256 | 1995-2013 | |
| 45 | Red Faber* | 254 | 1914-1933 | |
| 45 | Jack Morris | 254 | 1977-1994 | |
| 47 | Carl Hubbell* | 253 | 1928-1943 | |
| 48 | Bob Gibson* | 251 | 1959-1975 | |
| 49 | Vic Willis* | 249 | 1898-1910 | |
| 50 | Javier Covarrubias* | 245 | 2061-2077 | |
| 50 | Dennis Martinez | 245 | 1976-1998 | |
| 52 | Alex Batista* | 243 | 2058-2073 | |
| 52 | Juan Marichal* | 243 | 1960-1975 | |
| 54 | Herb Pennock* | 240 | 1912-1934 | |
| 54 | Frank Tanana | 240 | 1973-1993 | |
| 56 | Juan Fernandez* | 239 | 2053-2066 | |
| 56 | David Wells | 239 | 1987-2007 | |
| 58 | Devin Carl* | 238 | 2026-2043 | |
| 59 | Waite Hoyt* | 237 | 1918-1938 | |
| 59 | Ricardo Raya | 237 | 2030-2045 | |
| 61 | Whitey Ford* | 236 | 1950-1967 | |
| 62 | Amos Rusie* | 233 | 1890-1901 | |
| 63 | Javier Venzor* | 231 | 2022-2041 | |
| 64 | Sam Jones | 229 | 1914-1935 | |
| 64 | Luis Tiant | 229 | 1964-1982 | |
| 66 | Logan Lowe* | 228 | 2062-2079 | |
| 66 | Evan Parker* | 228 | 2070-2086 | |
| 68 | Roberto Arceo* | 227 | 2033-2049 | |
| 69 | Armando Almodovar* | 226 | 2020-2035 | |
| 69 | Manny Cruz* | 226 | 2027-2043 | |
| 71 | J.B. Bukauskas* | 225 | 2019-2036 | |
| 71 | Max Reyes* | 225 | 2031-2046 | |
| 73 | Jim Bunning* | 224 | 1955-1971 | |
| 73 | Bartolo Colon | 224 | 1997-2016 | |
| 73 | Catfish Hunter* | 224 | 1965-1979 | |
| 76 | Paul Derringer | 223 | 1931-1945 | |
| 76 | Clark Griffith* | 223 | 1893-1914 | |
| 76 | Mel Harder | 223 | 1928-1947 | |
| 79 | Hooks Dauss | 222 | 1912-1926 | |
| 79 | Tim Hudson | 222 | 1999-2015 | |
| 79 | Jerry Koosman | 222 | 1967-1985 | |
| 79 | Rafael Pulido | 222 | 2057-2074 | |
| 83 | Joe Niekro | 221 | 1967-1988 | |
| 84 | Jerry Reuss | 220 | 1969-1990 | |
| 85 | Pedro Martinez* | 219 | 1992-2009 | |
| 85 | Kenny Rogers | 219 | 1989-2008 | |
| 85 | CC Sabathia | 219 | 2001-2016 | |
| 85 | Claudio Scotti* | 219 | 2018-2035 | |
| 89 | Earl Whitehill | 218 | 1923-1939 | |
| 90 | Mark Buehrle | 217 | 2000-2016 | |
| 90 | Steve Chase | 217 | 2078-2093 | |
| 90 | David DePriest* | 217 | 2051-2064 | |
| 90 | Jeremy Fields | 217 | 2052-2070 | |
| 90 | Freddie Fitzsimmons | 217 | 1925-1943 | |
| 90 | Mickey Lolich | 217 | 1963-1979 | |
| 96 | Wilbur Cooper | 216 | 1912-1926 | |
| 96 | Charlie Hough | 216 | 1970-1994 | |
| 96 | Edwin Morel | 216 | 2065-2081 | |
| 96 | Curt Schilling | 216 | 1988-2007 | |
| 100 | Steve Coutts | 215 | 2077-2094 |
