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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Aroldis Chapman | .1831 | 2010-2030 | |
| 2 | Javier Covarrubias* | .1878 | 2061-2077 | |
| 3 | Jon Hoch | .1918 | 2076-2091 | |
| 4 | Tony Soto# | .1923 | 2088-2098 | |
| 5 | Jose Rubio* | .1938 | 2060-2079 | |
| 6 | Cody Allen | .1977 | 2012-2029 | |
| 7 | Jason Hudgins# | .1984 | 2092-2098 | |
| 8 | Juan Castorena | .1988 | 2053-2070 | |
| 9 | Nolan Ryan* | .2007 | 1966-1993 | |
| 10 | Juan Fernandez* | .2010 | 2053-2066 | |
| 11 | Sandy Koufax* | .2036 | 1955-1966 | |
| 12 | Kenley Jansen | .2046 | 2010-2026 | |
| 13 | Matt Gilman* | .2049 | 2051-2071 | |
| 14 | Sid Fernandez | .2066 | 1983-1997 | |
| 15 | Akeel Morris | .2079 | 2015-2030 | |
| 16 | Ray Carpenter | .2081 | 2047-2060 | |
| 17 | Jason Williams# | .2084 | 2093-2098 | |
| 18 | Rich Mathieu | .2085 | 2065-2077 | |
| 19 | J.R. Richard | .2090 | 1971-1980 | |
| 20 | Francisco Rodriguez | .2091 | 2002-2019 | |
| 21 | Andy Messersmith | .2095 | 1968-1979 | |
| 22 | Jesus Godinez | .2098 | 2056-2063 | |
| 23 | Dan White | .2102 | 2077-2091 | |
| 24 | Ken Giles | .2104 | 2014-2030 | |
| 25 | Trevor Hoffman | .2108 | 1993-2010 | |
| 25 | Sean Lebron | .2108 | 2061-2073 | |
| 27 | Mariano Rivera* | .2110 | 1995-2013 | |
| 28 | Nick Cerqueira | .2113 | 2055-2066 | |
| 29 | George Zimmerman | .2116 | 2052-2065 | |
| 30 | Starlin Cordero | .2117 | 2021-2038 | |
| 31 | Chris Flores | .2119 | 2060-2071 | |
| 32 | Rich Robichaud | .2122 | 2031-2046 | |
| 33 | Pedro Martinez* | .2123 | 1992-2009 | |
| 34 | Ed Walsh* | .2125 | 1904-1917 | |
| 35 | Hoyt Wilhelm* | .2126 | 1952-1972 | |
| 36 | Liu-chun Cui* | .2130 | 2038-2053 | |
| 37 | Sam McDowell | .2131 | 1961-1975 | |
| 37 | Chris Hafer# | .2131 | 2091-2098 | |
| 39 | Kerry Wood | .2134 | 1998-2012 | |
| 40 | Leo Monrreal* | .2139 | 2031-2044 | |
| 41 | Sean Sherman | .2142 | 2082-2097 | |
| 42 | Steve Scruggs | .2144 | 2080-2094 | |
| 43 | Babe Ruth* | .2147 | 1914-1935 | |
| 44 | Addie Joss* | .2149 | 1902-1910 | |
| 45 | Keith Lau | .2154 | 2035-2051 | |
| 46 | Jeremy LeVan | .2157 | 2053-2064 | |
| 47 | Brian Jones | .2159 | 2061-2075 | |
| 48 | Paul Tate | .2160 | 2052-2062 | |
| 48 | Joel Peterson | .2160 | 2059-2071 | |
| 48 | Alfredo Ceja | .2160 | 2040-2055 | |
| 51 | Yunior Perez* | .2165 | 2021-2037 | |
| 52 | Victor Diaz | .2166 | 2020-2032 | |
| 53 | Bob Turley | .2168 | 1951-1963 | |
| 53 | Dan Howery | .2168 | 2034-2051 | |
| 55 | Dave Boswell | .2169 | 1964-1971 | |
| 55 | Ed Reulbach | .2169 | 1905-1917 | |
| 55 | Carlos Rojas | .2169 | 2026-2035 | |
| 58 | Chris Clark | .2170 | 2072-2086 | |
| 58 | Braxton Janke | .2170 | 2046-2060 | |
| 60 | Evan Parker* | .2175 | 2070-2086 | |
| 61 | Mario Soto | .2176 | 1977-1988 | |
| 62 | Danny Aristondo | .2177 | 2026-2038 | |
| 63 | Jorge Villalona# | .2178 | 2090-2098 | |
| 64 | Jeff Tesreau | .2179 | 1912-1918 | |
| 64 | Doug Hodges | .2179 | 2078-2093 | |
| 66 | Jeff Welsh | .2180 | 2054-2066 | |
| 67 | Randy Johnson* | .2181 | 1988-2009 | |
| 68 | Ismael Macias | .2184 | 2030-2048 | |
| 69 | Joe Wood | .2186 | 1908-1922 | |
| 70 | Jose Benitez# | .2189 | 2087-2098 | |
| 71 | Danny Avery | .2190 | 2054-2069 | |
| 72 | Don McMahon | .2193 | 1957-1974 | |
| 73 | Rube Waddell* | .2194 | 1900-1910 | |
| 74 | Josh Lowe | .2197 | 2033-2047 | |
| 74 | Rafael Campos | .2197 | 2049-2058 | |
| 76 | Jon Hartman | .2198 | 2046-2062 | |
| 76 | Vincent Velasquez | .2198 | 2015-2023 | |
| 78 | Eric DeSanto | .2201 | 2046-2061 | |
| 78 | Alex Soto* | .2201 | 2068-2087 | |
| 80 | Mario Segura* | .2204 | 2060-2080 | |
| 81 | Chris Lawler | .2205 | 2050-2060 | |
| 81 | Jake Pappas | .2205 | 2023-2042 | |
| 83 | Dusty Plummer# | .2209 | 2085-2098 | |
| 84 | Orval Overall | .2211 | 1905-1913 | |
| 85 | Austin Priester | .2212 | 2031-2045 | |
| 86 | Jose DeLeon | .2213 | 1983-1995 | |
| 86 | Jim Maloney | .2213 | 1960-1971 | |
| 88 | Pete Richert | .2214 | 1962-1974 | |
| 89 | Walter Johnson* | .2215 | 1907-1927 | |
| 89 | Colby Brown | .2215 | 2057-2068 | |
| 91 | Jonathan Papelbon | .2216 | 2005-2022 | |
| 92 | Brian Anderson | .2217 | 2052-2066 | |
| 92 | Jesse Orosco | .2217 | 1979-2003 | |
| 94 | Roger Diaz# | .2227 | 2090-2098 | |
| 94 | Clayton Kershaw* | .2227 | 2008-2029 | |
| 96 | Scott Gaimari | .2228 | 2080-2094 | |
| 96 | Matt Patras# | .2228 | 2092-2098 | |
| 98 | Jose Madrigal | .2231 | 2057-2071 | |
| 98 | Kilber Santana | .2231 | 2020-2040 | |
| 100 | Jack Pfiester | .2232 | 1903-1911 |
