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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Cy Young* | 316 | 1890-1911 | |
| 2 | Pud Galvin* | 303 | 1875-1892 | |
| 3 | Nolan Ryan* | 292 | 1966-1993 | |
| 4 | Walter Johnson* | 279 | 1907-1927 | |
| 5 | Phil Niekro* | 274 | 1964-1987 | |
| 6 | Gaylord Perry* | 265 | 1962-1983 | |
| 7 | Don Sutton* | 256 | 1966-1988 | |
| 8 | Eppa Rixey* | 251 | 1912-1933 | |
| 9 | Bert Blyleven* | 250 | 1970-1992 | |
| 10 | Robin Roberts* | 245 | 1948-1966 | |
| 10 | Warren Spahn* | 245 | 1942-1965 | |
| 12 | Steve Carlton* | 244 | 1965-1988 | |
| 12 | Early Wynn* | 244 | 1939-1963 | |
| 14 | Jim Kaat | 237 | 1959-1983 | |
| 15 | Frank Tanana | 236 | 1973-1993 | |
| 16 | Tommy John | 231 | 1963-1989 | |
| 17 | Bob Friend | 230 | 1951-1966 | |
| 17 | Ted Lyons* | 230 | 1923-1946 | |
| 19 | Jack Powell | 229 | 1899-1912 | |
| 20 | Greg Maddux* | 227 | 1986-2008 | |
| 21 | Fergie Jenkins* | 226 | 1965-1983 | |
| 22 | Tim Keefe* | 225 | 1880-1893 | |
| 22 | Red Ruffing* | 225 | 1924-1947 | |
| 24 | Bobo Newsom | 222 | 1929-1953 | |
| 25 | Sam Jones | 217 | 1914-1935 | |
| 26 | Charlie Hough | 216 | 1970-1994 | |
| 27 | Eric Pridemore | 215 | 2028-2046 | |
| 28 | Red Faber* | 213 | 1914-1933 | |
| 29 | Paul Derringer | 212 | 1931-1945 | |
| 29 | Burleigh Grimes* | 212 | 1916-1934 | |
| 31 | Mickey Welch* | 210 | 1880-1892 | |
| 32 | Jerry Koosman | 209 | 1967-1985 | |
| 32 | Jamie Moyer | 209 | 1986-2012 | |
| 34 | Pete Alexander* | 208 | 1911-1930 | |
| 34 | Kid Nichols* | 208 | 1890-1906 | |
| 36 | Tom Seaver* | 205 | 1967-1986 | |
| 36 | Vic Willis* | 205 | 1898-1910 | |
| 38 | Joe Niekro | 204 | 1967-1988 | |
| 39 | Tom Glavine* | 203 | 1987-2008 | |
| 40 | Mike Arkin | 196 | 2046-2063 | |
| 41 | Claude Osteen | 195 | 1957-1975 | |
| 42 | Dennis Martinez | 193 | 1976-1998 | |
| 43 | Mickey Lolich | 191 | 1963-1979 | |
| 43 | Rick Reuschel | 191 | 1972-1991 | |
| 43 | Jerry Reuss | 191 | 1969-1990 | |
| 43 | Tom Zachary | 191 | 1918-1936 | |
| 47 | Al Orth | 189 | 1895-1909 | |
| 48 | Christy Mathewson* | 188 | 1900-1916 | |
| 49 | Jesus Archuleta | 186 | 2081-2095 | |
| 49 | Mel Harder | 186 | 1928-1947 | |
| 49 | Mike Morgan | 186 | 1978-2002 | |
| 49 | Jack Morris | 186 | 1977-1994 | |
| 53 | Earl Whitehill | 185 | 1923-1939 | |
| 54 | Justin Allen | 184 | 2059-2073 | |
| 54 | Jim Bunning* | 184 | 1955-1971 | |
| 54 | Roger Clemens | 184 | 1984-2007 | |
| 54 | George Mullin | 184 | 1902-1913 | |
| 54 | Jordan Pardo Jr. | 184 | 2080-2095 | |
| 59 | Joe Bush | 183 | 1912-1928 | |
| 59 | Larry Jackson | 183 | 1955-1968 | |
| 59 | Eddie Plank* | 183 | 1901-1917 | |
| 59 | Charley Radbourn* | 183 | 1881-1891 | |
| 59 | Curt Simmons | 183 | 1947-1967 | |
| 64 | Danny Darwin | 182 | 1978-1998 | |
| 64 | Hooks Dauss | 182 | 1912-1926 | |
| 64 | Waite Hoyt* | 182 | 1918-1938 | |
| 64 | Jack Quinn | 182 | 1909-1933 | |
| 68 | Steve Chase | 181 | 2078-2093 | |
| 68 | Murry Dickson | 181 | 1939-1959 | |
| 68 | Dutch Leonard | 181 | 1933-1953 | |
| 68 | Rick Wise | 181 | 1964-1982 | |
| 72 | Lee Meadows | 180 | 1915-1929 | |
| 72 | Tim Wakefield | 180 | 1992-2011 | |
| 74 | Pink Hawley | 179 | 1892-1901 | |
| 74 | Dolf Luque | 179 | 1914-1935 | |
| 76 | Rick Benscoter | 178 | 2078-2095 | |
| 76 | John Clarkson* | 178 | 1882-1894 | |
| 76 | Wilbur Cooper | 178 | 1912-1926 | |
| 76 | Edwin Morel | 178 | 2065-2081 | |
| 80 | Livan Hernandez | 177 | 1996-2012 | |
| 80 | Rube Marquard* | 177 | 1908-1925 | |
| 82 | Bubba Kidd | 176 | 2050-2064 | |
| 82 | Mike Moore | 176 | 1982-1995 | |
| 84 | Red Donahue | 175 | 1893-1906 | |
| 84 | Rodrigo Santana | 175 | 2083-2097 | |
| 86 | Doyle Alexander | 174 | 1971-1989 | |
| 86 | Bob Gibson* | 174 | 1959-1975 | |
| 86 | Jim Perry | 174 | 1959-1975 | |
| 89 | Chuck Finley | 173 | 1986-2002 | |
| 89 | Caleb McAdams | 173 | 2040-2058 | |
| 89 | Ken Steinberg | 173 | 2053-2070 | |
| 92 | Dustin Draper | 172 | 2051-2065 | |
| 92 | Steve Hoskins | 172 | 2055-2073 | |
| 92 | Jonathan Long | 172 | 2080-2095 | |
| 92 | Pat Ogden* | 172 | 2040-2061 | |
| 92 | Luis Tiant | 172 | 1964-1982 | |
| 97 | Dennis Eckersley* | 171 | 1975-1998 | |
| 97 | Larry French | 171 | 1929-1942 | |
| 97 | Felix Hernandez* | 171 | 2005-2022 | |
| 97 | Luis Torres# | 171 | 2084-2098 |
