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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Gabriel | 2B | Free Agent | 23 | 07/02/2075 | Valencia | VEN | Right | Right | 6' 0" | 190 lbs | - |
| Salazar, Jonathan | SP | Free Agent | 24 | 05/26/2075 | Sabana Grande de Boya | DOM | Right | Right | 6' 6" | 200 lbs | - |
| Samaniego, Danny | 2B | Free Agent | 25 | 09/28/2073 | Maracaibo | VEN | Left | Right | 6' 1" | 200 lbs | - |
| Samari, Osvaldo | CF | Free Agent | 25 | 03/15/2074 | El Cafetal | VEN | Right | Right | 6' 6" | 200 lbs | - |
| Sanchez, Willie | 2B | Free Agent | 24 | 05/07/2075 | Caracas | VEN | Right | Right | 5' 11" | 180 lbs | - |
| Sandino, Felix | RF | Lynchburg Hillcats | 23 | 04/23/2076 | Cotuí | DOM | Right | Left | 6' 2" | 180 lbs | - |
| Sandoval, Danny | SP | Free Agent | 22 | 11/18/2076 | La Romana | DOM | Left | Left | 6' 1" | 185 lbs | - |
| Sandoval, Gustavo | SP | Carolina Mudcats | 22 | 05/01/2077 | Higüey | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Santa Ana, Keith | RP | Free Agent | 29 | 12/18/2069 | Racine | USA | Left | Left | 6' 0" | 200 lbs | - |
| Santos, Leon | C | Winston-Salem Dash | 24 | 05/29/2075 | Caracas | VEN | Right | Right | 6' 1" | 200 lbs | - |
| Saucedo, Jose | CL | Potomac Nationals | 24 | 04/20/2075 | Naguanagua | VEN | Left | Left | 6' 5" | 200 lbs | - |
| Savage, Eric | RP | Frederick Keys | 23 | 02/03/2076 | New Albany | USA | Left | Left | 6' 8" | 200 lbs | - |
| Scappaticci, Justin | SS | Salem Red Sox | 27 | 10/29/2071 | Sharon | USA | Left | Right | 6' 3" | 200 lbs | $1,380,000 |
| Schillaci, James | SP | Frederick Keys | 23 | 11/15/2075 | Columbus | USA | Left | Left | 6' 3" | 200 lbs | - |
| Schmidt, Vince | RP | Wilmington Blue Rocks | 29 | 12/13/2069 | Miami | USA | Right | Right | 6' 3" | 200 lbs | - |
| Scholtens, Pascal | RP | Carolina Mudcats | 21 | 09/03/2077 | Kralendijk | ANT | Right | Right | 6' 3" | 185 lbs | - |
| Serrano, Jose | RP | Wilmington Blue Rocks | 24 | 06/28/2074 | Valencia | VEN | Right | Right | 6' 2" | 200 lbs | - |
| Sexton, Mike | CF | Frederick Keys | 20 | 03/11/2079 | Deerfield Beach | USA | Right | Right | 6' 1" | 175 lbs | - |
| Sheeley, Josh | CL | Wilmington Blue Rocks | 31 | 12/30/2067 | Willingboro Township | USA | Right | Right | 6' 9" | 200 lbs | - |
| Shepherd, Gabe | 3B | Wilmington Blue Rocks | 26 | 06/26/2072 | Citrus Springs | USA | Right | Right | 5' 10" | 190 lbs | - |
| Shortall, Tom | RP | Potomac Nationals | 22 | 06/13/2076 | Saskatoon | CAN | Switch | Right | 6' 3" | 200 lbs | - |
| Shuford, Chris | 2B | Lynchburg Hillcats | 24 | 02/10/2075 | Carlyle | USA | Left | Right | 6' 0" | 185 lbs | - |
| Sinkler, Michael | RP | Free Agent | 27 | 10/29/2071 | Columbus | USA | Right | Right | 6' 0" | 190 lbs | - |
| Smithwick, Brad | SP | Wilmington Blue Rocks | 23 | 04/18/2076 | Scottsdale | USA | Left | Left | 6' 0" | 185 lbs | - |
| Solis, Ricardo | RP | Salem Red Sox | 30 | 06/30/2068 | Barquisimeto | VEN | Right | Right | 6' 2" | 195 lbs | - |
| Soto, Josue | 1B | Free Agent | 24 | 06/11/2074 | Orocovis | PUR | Left | Right | 6' 4" | 200 lbs | - |
| Soto, Victor | RF | Potomac Nationals | 26 | 02/21/2073 | San Pedro de Macorís | DOM | Right | Right | 6' 5" | 205 lbs | - |
| Spraggins, Bryce | 2B | Winston-Salem Dash | 23 | 08/01/2075 | Sheldon | USA | Right | Right | 6' 5" | 200 lbs | - |
| Stewart, Jake | RP | Salem Red Sox | 31 | 09/10/2067 | Albany | USA | Right | Right | 6' 4" | 200 lbs | - |
| Strasser, Philip | C | Frederick Keys | 23 | 02/07/2076 | Hartford | USA | Right | Right | 6' 0" | 190 lbs | - |
| Straub, John | CF | Lynchburg Hillcats | 26 | 02/19/2073 | Weaverville | USA | Right | Right | 6' 4" | 205 lbs | - |
| Sutherlin, Mike | RP | Frederick Keys | 25 | 06/25/2073 | Rockford | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sweet, Ben | RP | Lynchburg Hillcats | 29 | 08/12/2069 | Vernon | USA | Right | Right | 6' 4" | 200 lbs | $3,200,000 |
