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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanchez, Danny | RF | Palm Beach Cardinals | 23 | 05/18/2092 | Puerto Plata | DOM | Left | Left | 6' 2" | 200 lbs | - |
| Sanchez, Ramon | RF | Lakeland Flying Tigers | 22 | 01/29/2093 | Miches | DOM | Right | Right | 6' 1" | 180 lbs | $1,300,000 |
| Sanchez, Tony | SP | Daytona Tortugas | 23 | 05/26/2092 | Sabana de la Mar | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Sandoval, Mario | C | Tampa Yankees | 24 | 08/14/2091 | Santo Domingo | DOM | Right | Right | 6' 7" | 205 lbs | - |
| Santiago, Oscar | RP | Charlotte Stone Crabs | 23 | 03/03/2092 | Santana | DOM | Right | Right | 6' 4" | 195 lbs | - |
| Saragosa, Bob | SP | Free Agent | 23 | 06/17/2092 | Santo Domingo | DOM | Right | Right | 6' 1" | 190 lbs | - |
| Sax, Bastião | SP | St. Lucie Mets | 24 | 07/20/2091 | Barquisimeto | VEN | Switch | Left | 6' 5" | 200 lbs | - |
| Schaefer, Dan | CF | Dunedin Blue Jays | 21 | 05/14/2094 | Colona | USA | Left | Left | 6' 3" | 200 lbs | - |
| Schaefer, Kurt | SP | Dunedin Blue Jays | 21 | 03/17/2094 | Benton | USA | Right | Right | 6' 2" | 180 lbs | - |
| Schomber, Gabe | RF | Lakeland Flying Tigers | 22 | 12/22/2092 | West Milford | USA | Left | Left | 6' 3" | 200 lbs | - |
| Schultz, Chris | SS | Jupiter Hammerheads | 23 | 03/02/2092 | Woodbury | USA | Right | Right | 6' 0" | 180 lbs | - |
| Schulz, Joe | C | Charlotte Stone Crabs | 23 | 05/26/2092 | Detroit | USA | Right | Right | 6' 0" | 200 lbs | - |
| Schweers, Mark | LF | Palm Beach Cardinals | 25 | 06/10/2090 | Highland | USA | Right | Left | 6' 4" | 215 lbs | - |
| Secore, Kyle | CF | Palm Beach Cardinals | 25 | 08/12/2090 | Ingram | USA | Left | Left | 6' 2" | 205 lbs | - |
| Seitz, Eric | CF | Dunedin Blue Jays | 23 | 08/28/2092 | Caledonia | USA | Right | Right | 6' 0" | 190 lbs | - |
| Serl, Terry | SS | Daytona Tortugas | 19 | 11/19/2095 | Santa Ana | USA | Left | Right | 6' 2" | 190 lbs | - |
| Serrano, Nesty | 3B | Daytona Tortugas | 22 | 12/03/2092 | Caracas | VEN | Right | Right | 6' 3" | 210 lbs | - |
| Seymour, John | C | Fort Myers Miracle | 23 | 11/13/2091 | Aurora | USA | Right | Right | 6' 0" | 205 lbs | - |
| Sharpe, John | 1B | Palm Beach Cardinals | 22 | 08/08/2093 | Tamiami | USA | Left | Left | 6' 4" | 240 lbs | - |
| Shearing, Glenn | RP | Bradenton Marauders | 24 | 07/12/2091 | Mascouche | CAN | Switch | Right | 6' 1" | 190 lbs | - |
| Sheldon, Sean | CF | Clearwater Threshers | 24 | 02/02/2091 | Beloit | USA | Right | Left | 6' 2" | 200 lbs | - |
| Shimoda, Chris | 1B | Dunedin Blue Jays | 25 | 10/18/2089 | Black Forest | USA | Switch | Right | 6' 5" | 220 lbs | - |
| Shore, Sean | CF | Bradenton Marauders | 24 | 07/13/2091 | Phoenix | USA | Right | Right | 6' 1" | 190 lbs | - |
| Siegel, Pat | CL | Palm Beach Cardinals | 22 | 06/12/2093 | Gloversville | USA | Right | Right | 6' 0" | 185 lbs | - |
| Silva, Marco | C | Free Agent | 24 | 03/27/2091 | Caracas | VEN | Left | Right | 6' 2" | 200 lbs | - |
| Silva, Mario | CF | Free Agent | 20 | 07/11/2095 | San Pedro de Macorís | DOM | Left | Right | 6' 4" | 195 lbs | - |
| Silva, Mario | 2B | Free Agent | 24 | 11/18/2090 | Santo Domingo | DOM | Right | Right | 6' 0" | 185 lbs | - |
| Sinchi, Luis | 3B | Charlotte Stone Crabs | 26 | 09/13/2089 | Burgaw | USA | Right | Right | 6' 3" | 205 lbs | - |
| Skeels, Matt | SP | Bradenton Marauders | 27 | 05/31/2088 | Baton Rouge | USA | Right | Right | 6' 4" | 200 lbs | - |
| Smedley, Jesse | SP | Free Agent | 28 | 06/22/2087 | Macon | USA | Right | Right | 6' 1" | 195 lbs | - |
| Snodgrass, Andrew | RP | Jupiter Hammerheads | 23 | 05/16/2092 | Paradise | USA | Left | Left | 6' 1" | 190 lbs | - |
| Stallings, Ryan | RP | Free Agent | 24 | 03/03/2091 | East Palo Alto | USA | Right | Right | 6' 8" | 200 lbs | - |
| Stephens, Brian | SP | Bradenton Marauders | 24 | 08/09/2091 | Fond du Lac | USA | Left | Left | 5' 10" | 175 lbs | - |
| Stephens, Danny | SP | Palm Beach Cardinals | 23 | 04/14/2092 | Swansea | USA | Right | Right | 6' 0" | 190 lbs | - |
| Stevens, Aiden | 1B | Free Agent | 27 | 01/02/2088 | Wilson | USA | Right | Right | 6' 4" | 205 lbs | - |
| Stewart, Jayden | SS | Jupiter Hammerheads | 24 | 10/16/2090 | Tampa | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stock, Brian | SP | Bradenton Marauders | 25 | 07/23/2090 | Hearne | USA | Right | Right | 6' 0" | 195 lbs | - |
| Stokes, Nick | RP | Jupiter Hammerheads | 21 | 05/18/2094 | Laredo | USA | Right | Right | 6' 4" | 190 lbs | - |
| Stonecipher, Jim | 2B | Brevard County Manatees | 24 | 06/16/2091 | Tulsa | USA | Left | Right | 6' 1" | 185 lbs | - |
| Strickland, Justin | RP | Charlotte Stone Crabs | 25 | 01/31/2090 | San Diego | USA | Left | Left | 5' 10" | 185 lbs | - |
