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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saenz, Jesus | RF | Philadelphia (GCL) Phillies | 19 | 05/29/2080 | Moca | DOM | Left | Left | 6' 0" | 175 lbs | - |
| Salazar, Fernando | SS | New York A (GCL) Yankees | 18 | 01/06/2081 | Samana | DOM | Switch | Right | 6' 1" | 175 lbs | - |
| Salgado, Miguel | C | Philadelphia (GCL) Phillies | 19 | 10/27/2079 | Mexicali | MEX | Left | Right | 6' 2" | 190 lbs | - |
| Salum, Michael | CF | New York N (GCL) Mets | 21 | 09/20/2077 | Constanza | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Sanchez, Alex | SP | Free Agent | 20 | 01/03/2079 | Comendador | DOM | Switch | Right | 6' 4" | 200 lbs | - |
| Sanchez, Bob | 2B | Minnesota (GCL) Twins | 19 | 02/28/2080 | San Miguelito | PAN | Right | Right | 6' 0" | 175 lbs | - |
| Sanchez, Carlos | 2B | Free Agent | 23 | 04/27/2076 | Villahermosa | MEX | Right | Right | 6' 2" | 200 lbs | - |
| Sanchez, Elias | SP | Pittsburgh (GCL) Pirates | 17 | 11/25/2081 | Cardenas | CUB | Left | Right | 5' 11" | 165 lbs | - |
| Sandoval, Jorge | SP | New York N (GCL) Mets | 19 | 03/15/2080 | Lubbock | USA | Right | Right | 5' 10" | 160 lbs | - |
| Sandoval, Miguel | LF | St. Louis (GCL) Cardinals | 20 | 12/05/2078 | San Pedro de Macorís | DOM | Left | Left | 6' 6" | 210 lbs | - |
| Santiago, Danny | RF | Baltimore (GCL) Orioles | 20 | 01/15/2079 | Postrer Río | DOM | Right | Left | 6' 3" | 195 lbs | - |
| Santiago, Mario | SP | Toronto (GCL) Blue Jays | 20 | 02/24/2079 | Caucagüita | VEN | Right | Right | 6' 5" | 195 lbs | - |
| Santiago, Tom | C | St. Louis (GCL) Cardinals | 23 | 08/29/2075 | Vashon | USA | Right | Right | 6' 4" | 200 lbs | - |
| Schilperoort, Itze | 3B | St. Louis (GCL) Cardinals | 20 | 09/18/2078 | Santa Cruz | ARU | Right | Right | 6' 3" | 190 lbs | - |
| Schwarberg, Aaron | SP | Boston (GCL) Red Sox | 19 | 11/18/2079 | Smithtown | USA | Left | Left | 6' 5" | 200 lbs | - |
| Scotti, Bill | RF | Washington (GCL) Nationals | 20 | 09/14/2078 | Chicago | USA | Left | Left | 6' 7" | 200 lbs | - |
| Segovia, Jose | RP | Tampa Bay (GCL) Rays | 18 | 07/12/2080 | Plan de Ayala | MEX | Right | Right | 6' 2" | 185 lbs | - |
| Sena, Maximo | SP | Toronto (GCL) Blue Jays | 20 | 09/04/2078 | Gragnano | ITA | Right | Right | 5' 10" | 160 lbs | - |
| Serna, Tony | RP | Colorado (GCL) Rockies | 19 | 12/19/2079 | Charallave | VEN | Right | Right | 6' 2" | 185 lbs | - |
| Setters, Craig | C | St. Louis (GCL) Cardinals | 22 | 10/30/2076 | Rocky Mount | USA | Right | Right | 6' 4" | 210 lbs | - |
| Shindle, Travis | SP | Houston (GCL) Astros | 19 | 05/22/2080 | University | USA | Right | Right | 5' 11" | 165 lbs | - |
| Shipman, Jim | 3B | Boston (GCL) Red Sox | 20 | 04/18/2079 | Garland | USA | Right | Right | 6' 4" | 185 lbs | - |
| Shoemaker, Eric | 1B | New York N (GCL) Mets | 20 | 08/23/2078 | East Meadow | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sierra, Israel | SP | Las Vegas (GCL) Hustle | 18 | 01/26/2081 | Santo Domingo | DOM | Right | Right | 6' 9" | 210 lbs | - |
| Silva, Mauricio | SP | Baltimore (GCL) Orioles | 22 | 01/11/2077 | Barcelona | VEN | Left | Right | 6' 3" | 195 lbs | - |
| Simpson, Christian | RF | Houston (GCL) Astros | 20 | 11/02/2078 | Crescent Hill | USA | Right | Right | 5' 11" | 175 lbs | - |
| Sims, Clint | SP | Pittsburgh (GCL) Pirates | 19 | 01/08/2080 | Forest | USA | Right | Left | 6' 7" | 190 lbs | - |
| Skelton, Jim | CF | Philadelphia (GCL) Phillies | 19 | 01/01/2080 | Memphis | USA | Left | Left | 6' 2" | 175 lbs | - |
| Smythe, Dave | RF | Philadelphia (GCL) Phillies | 18 | 06/17/2080 | Cromwell | USA | Right | Left | 6' 2" | 185 lbs | - |
| Snyder, Jim | CF | St. Louis (GCL) Cardinals | 22 | 01/31/2077 | Dallas | USA | Right | Right | 6' 1" | 190 lbs | - |
| Solana, Tony | 2B | Colorado (GCL) Rockies | 20 | 07/24/2078 | San Cristóbal | DOM | Right | Right | 6' 4" | 195 lbs | - |
| Solis, Pedro | 2B | Minnesota (GCL) Twins | 21 | 10/24/2077 | Santo Domingo | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Solorio, Ernesto | SP | Atlanta (GCL) Braves | 20 | 04/17/2079 | Bajos de Haina | DOM | Left | Left | 5' 11" | 175 lbs | - |
| Solorzano, Tony | RP | Baltimore (GCL) Orioles | 21 | 06/29/2077 | Santo Domingo | DOM | Right | Right | 6' 7" | 200 lbs | - |
| Staff, Ben | CF | Detroit (GCL) Tigers | 19 | 06/30/2079 | Anaheim | USA | Right | Right | 6' 2" | 190 lbs | - |
| Stone, Derrick | 3B | Houston (GCL) Astros | 20 | 11/19/2078 | Rubidoux | USA | Left | Right | 6' 3" | 185 lbs | - |
| Sullo, Craig | C | St. Louis (GCL) Cardinals | 20 | 11/17/2078 | Anchorage | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sweetman, Jason | 2B | Free Agent | 19 | 10/23/2079 | Rochester | USA | Right | Right | 6' 4" | 185 lbs | - |
